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if you have trouble falling asleep or staying asleep, do not take bupropion too close to bedtime.

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following oral administration of two 150 mg tablets of the sustained-release formulation of bupropion with and without 800 mg of cimetidine, the pharmacokinetics of bupropion and hydroxybupropion were unaffected.

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in contrast to what was described in animal studies, human in vivo research suggests that bupropion effects on dopamine are relatively modest.

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bupropion should not be combined with sedatives, maois, alcohol and many other medications and must be tapered.
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