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This was an adequate and well-controlled, two-year study evaluating the efficacy of clozaril relative to olanzapine in reducing the risk of suicidal behavior in patients with schizophrenia or schizoaffective disorder.

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Use clozaril cautiously in patients with cardiovascular disease history of myocardial infarction or ischemia, heart failure, or conduction abnormalities , cerebrovascular disease, and conditions which would predispose patients to hypotension e.

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Drug selection table for schizoaffective disorder class drug antipsychotic drugs, atypical second generation first-line drug therapy aripiprazole abilify, abilify discmelt odt, abilify liquid, abilify im injection, long-acting abilify once monthly injection clozapine clozaril, fazaclo olanzapine zyprexa relprevv risperidone risperdal, risperdal consta quetiapine seroquel, seroquel xr ziprasidone geodon, geodon im injection paliperidone invega, invega sustenna long acting asenapine saphris antipsychotic drugs, typical first generation second-line drug therapy haloperidol haldol fluphenazine prolixin selective serotorin reuptake ssris adjunct treatment for mood or depression fluoxetine prozac paroxetine paxil sertraline zoloft mood stabilizers adjunct treatment for mood; also approved for bipolar mania, includes carbamazepine, lamotrigine–same as depakote lithium eskalith, lithobid, lithium carbonate valproate depakote divalproex depakote er tablets, and the regular delayed-release tablet im, intramuscular.

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The clozaril dose should be increased to the original dose when coadministration of strong cyp1a2 inhibitors is discontinued.

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