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This was an adequate and well-controlled, two-year study evaluating the efficacy of clozaril relative to olanzapine in reducing the risk of suicidal behavior in patients with schizophrenia or schizoaffective disorder.

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Use clozaril cautiously in patients with cardiovascular disease history of myocardial infarction or ischemia, heart failure, or conduction abnormalities , cerebrovascular disease, and conditions which would predispose patients to hypotension e.

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Drug selection table for schizoaffective disorder class drug antipsychotic drugs, atypical second generation first-line drug therapy aripiprazole abilify, abilify discmelt odt, abilify liquid, abilify im injection, long-acting abilify once monthly injection clozapine clozaril, fazaclo olanzapine zyprexa relprevv risperidone risperdal, risperdal consta quetiapine seroquel, seroquel xr ziprasidone geodon, geodon im injection paliperidone invega, invega sustenna long acting asenapine saphris antipsychotic drugs, typical first generation second-line drug therapy haloperidol haldol fluphenazine prolixin selective serotorin reuptake ssris adjunct treatment for mood or depression fluoxetine prozac paroxetine paxil sertraline zoloft mood stabilizers adjunct treatment for mood; also approved for bipolar mania, includes carbamazepine, lamotrigine–same as depakote lithium eskalith, lithobid, lithium carbonate valproate depakote divalproex depakote er tablets, and the regular delayed-release tablet im, intramuscular.

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The clozaril dose should be increased to the original dose when coadministration of strong cyp1a2 inhibitors is discontinued.

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mao inhibitors within 14 days – serious, even fatal interactions can occur when taken with tegretol alcohol – when taken with tegretol can dangerously lower blood pressure seldane terfenadine , prozac fluoxetine , luvox fluvoxamine , and rifampin – can lead to drug toxicity tranquilizers, hypnotics, and narcotics – tegretol can increase the effects of these drugs adrenocortical steroids, antidepressants, birth control pills, sandimmune cyclosporine , doxy-ii and vibramycin doxycycline , plendil felodipine , haldol haloperidol , dynacirc isradipine , sporanox itraconazole , tetracyclines, depakene valproic acid , and coumadin warfarin – tegretol can decrease the effects of these drugs clozaril clozapine – can cause serious bone marrow suppression when taken with tegretol felbatol felbamate – can reduce the body s levels of tegretol lithium – taken with tegretol can cause neurological problems such as confusion, tremors, and weakness dilanin phenytoin – can impair seizure control due to fluctuation of blood levels theo-dur theophylline – when taken with tegretol, the effects of both of these drugs can decrease tagamet cimetidine , danocrine danazol , cardizem diltiazem , flu shots, inh isoniazid , erythromycin and other macrolide antibiotics, nicotinamide, darvon propoxyphene , norvir ritonavir , and calan isoptin verapamil – these drugs may increase the effects of tegretol phenobarbital and biaxin clarithromycin – can increase the toxicity of tegretol.

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