Rosuvastatin is a selective and competitive inhibitor of hmg-coa reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme a to mevalonate, a precursor for cholesterol.
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the chemical name for rosuvastatin calcium is bis e -7- 4 4-fluorophenyl -6-isopropyl-2- methyl methylsulfonyl amino pyrimidin-5-yl 3r,5s -3,5-dihydroxyhept-6-enoic acid calcium salt with the following structural formula .
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in particular, management s expectations could be affected by, among other things, unexpected regulatory actions or delays or government regulation generally; competition in general, including potential approval of additional versions of rosuvastatin calcium for sale either before or after the end of sandoz expected 180-day exclusivity period; government, industry and general public pricing pressures; unexpected patent litigation outcomes; unexpected manufacturing issues; general economic and industry conditions, and other risks and factors referred to in novartis ag s current form 20-f on file with the us securities and exchange commission.
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and dried under vacuum at room temperature to provide 204 mg of rosuvastatin calcium rsvca as an off-white solid with a molar yield of 82 .
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